Your Key to Prostate, Overall Health and Longevity!
- “Powerful antioxidant synergistic blend of Pomegranate and Quercetin”
- “Pometin effectively counteracts dangerous effects frombad LDL cholesterol”
- “Lowers the risk for cardiovascular disease”
- “Stabilises blood sugar and fight cravings”
- “Improves erectile response”
- “Indicated protection against prostate cancer”
There is no doubt that a high intake of nutritious vegetables and fruits is healthy. Unfortunately, scientific studies rarely indicate any health promoting effects from use of multivitamins. The reason is that vegetables and fruits contain several hundreds of other substances besides vitamins and minerals, e.g. polyphenols and flavonoids. Apples are especially rich in these compounds. Not surprisingly, epidemiological studies have linked the consumption of apples with reduced risk of some cancers, cardiovascular disease, asthma, and diabetes; even more so than other fruits or vegetables (1). Recent research shows that pomegranate in particular, a fruit that resembles apple, has impressive health bringing properties.
Pometin contains two types of extracts with highly bioactive natural compounds:
- Pomegranate extract is derived from the peel, the most nutritious part of the fruit.
- Quercetin extract is of particularly high concentration and quality.
No ingredients, including the capsules, are derived from animal sources.
Pomegranate resembles an ordinary red apple. However, the inside is another story. It is mainly the content of ellagic acid - a polyphenol that also exists in nuts - that has generated interest in the scientific community. Pomegranate extracts with a high content of ellagic acid have shown to inhibit inflammation (2), virus and bacterial growth (3,4), and dramatically enhance the activity of antibiotics (5). Furthermore, pomegranate helps the liver to fight toxins. The extract is also a powerful anti-oxidant. In fact, it is even more potent than red wine and green tea (7). Pomegranate extract can be used orally to protect the skin from free radical generating sun exposure and damage (8).
A very interesting property of Pomegranate is that it counteracts the dangerous effects of LDL-particles (a.k.a “bad cholesterol”). When this type of cholesterol attaches to the wall of your blood vessels, atherosclerosis emerges, and the risk of heart attack or stroke increases. However, in order to make this happen the cholesterol must be oxidised, and inflammation must be present. Pomegranate inhibits these conditions effectively (9-11). In fact, atherosclerosis that once was seen as a chronic disease has been reduced by 30% after three years of pomegranate juice drinking (11). In this particular study, blood pressure was also lowered. In other human studies this effect was seen already after two weeks of pomegranate supplementation (12).
Lately pomegranate has been covered extensively in the media due to new findings regarding its ability to fight cancers, in particular breast cancer (13) and prostate cancer (14-16). Although at present there are mostly animal studies available, the data is nevertheless very impressive. Human studies have indicated a decrease in PSA concentration (a marker of prostate cancer), and that ellagic acid decreases the side effects from chemotherapy (16). Another interesting effect of pomegranate is that it decreases the uptake of sugars from the intestines (17). This results in a more stable blood sugar level, with less cravings. Scientists also believe that pomegranate extract can inhibit osteoporosis and improve the depressive state in menopausal women (18) and to inhibit osteoarthritis (19). After researchers investigated several natural substances they concluded that pomegranate was the most effective substance for improving erectile response (20).
Another health promoting substance found in apples is quercetin, which belongs to a group of natural substances called flavonoids. Quercetin can also be found in red wine, black tea and onions, and it is one of the substances that confers the beneficial health effects seen with moderate intake of red wine (21). In the Western world we eat about 15 mg quercetin daily, which corresponds to 750 ml of red wine, 50 grams of onion or 375 ml of tea (22). Red apples, but not pomegranate, are another important source of quercetin. To get 15 mg of quercetin one needs to ingest almost ½ kg (1 lb) of apples.
In a large Dutch study it was found that there is a close relation between quercetin intake and cardiovascular disease (23). A group of Finish researchers have been following 10,054 males since 1966. The leader of the project, Dr Paul Knekt, has concluded that the individuals who consumed the largest amounts of apples (especially apples with high quercetin content) had the lowest risk of cardiovascular disease (24). Furthermore, the more apples the men were eating, the lower risk of cancer, asthma and diabetes type 2 (24).
In several ways quercetin works similarly to ellagic acid (anti-inflammatory, anti-oxidatively, blood pressure lowering), but quercetin also seems to affect platelets, and thus also decreases the risk of thrombosis (24). Another unique property of quercetin is that it protects the body from harmful effects induced by a high blood sugar (26). Furthermore, quercetin seems to protect the kidneys from damage. In rat studies the kidney damage from toxin exposure was dramatically decreased when quercetin was adminstered (27). Together with ellagic acid quercetin seems to protect against prostate cancer, but quercetin can also reduce the symptoms from prostatitis (inflammation of the prostate gland). This is an unpleasant condition that is difficult to treat otherwise. In a recent pilot study, an extract of quercetin was effective in treating pain from the female genitals (29).
In conclusion, the old expression ”An apple a day, keeps the doctor away” is well backed up by rigorous research. Pometin, being a concentrated source of the major heatlh promoting substances found in apples and pomegranate, will help you reap the full health benefits.
1. Boyer J & Liu RH. Apple phytochemicals and their health benefits. Nutr J. 2004 May 12;3:5.
2. Gil, M. I et al Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J. Agric. Food Chem. 2000, 10:4581-4589
3. Zhang J et al. Anti-viral activity of tannin from the pericarp of Punica granatum L. against genital Herpes virus in vitro. Chung Kuo Chung Yao Tsa Chin 20 (1995), pp.556–558.
4. Braga LC et al. Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production. J Ethnopharmacol. 2005 Jan 4;96(1-2):335-9.
5. Braga LC et al . Synergic interaction between pomegranate extract and antibiotics against Staphylococcus aureus. Can J Microbiol. 2005 Jul;51(7):541-7.
6. Sudheesh S & Vijayalakshmi NR. Flavonoids from Punica granatum - potential antiperoxidative agents. Fitoterapia. 2005 Mar;76(2):181-6.
7. Gil MI et al Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 2000 Oct;48(10):4581
8. Murad H & Shellow W. A study on Pomegranate Extract Both Orally Ingested and Topically Applied to Augment the SPF of Sunscreens, August 1999.
9. Aviram M et al. Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. Drugs Exp Clin Res. 2002;28(2-3):49-62.
10. Esmaillzadeh A et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food. 2004 Fall;7(3):305-8.
11. Aviram M et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004 Jun;23(3):423-33
12. Aviram M & Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001 Sep;158(1):195-8
13. Kim ND et al. Breast Cancer Res Treat. 2002 Feb;71(3):203-17. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer.
14. Malik A et al. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14813-8. Epub 2005 Sep 28.
15. Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food. 2004 Fall;7(3):274-83.
16. Falsaperla M et al. Support Ellagic Acid Therapy in Patients with Hormone Refractory Prostate Cancer (HRPC) on Standard Chemotherapy Using Vinorelbine and Estramustine Phosphate. European Urology, Volume 47, Issue 4, Pages 449-455
17. Li Y et al. Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol. 2005 Jun 3;99(2):239-44. Epub 2005 Apr 9.
18. Mori-Okamoto J et al. Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. J Ethnopharmacol. 2004 May;92(1):93-101.
19. Ahmed S et al Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NFkappaB in human chondrocytes in vitro. J Nutr. 2005 Sep;135(9):2096-102.
20. Azadzoi KM et al. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. J Urol. 2005 Jul;174(1):386-93.
21. Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron Artery Dis. 1997 Oct;8(10):645-9. Review
22. de Vries JH et al. Red wine is a poor source of bioavailable flavonols in men. J Nutr. 2001 Mar;131(3):745-8
23. Keli SO, et al. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 1996 Mar 25;156(6):637-42.
24. Knekt P et al Flavonoid intake and risk of chronic diseases. Am J Clin Nutr. 2002 Sep;76(3):560-8.
25. Pignatelli P, et al. The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. Am J Clin Nutr 2000;72:1150-5.
26. Varma SD et al Implications of aldose reductase in cataracts in human diabetes. Invest Ophthalmol Vis Sci. 1979 Mar;18(3):237-41.
27. Satyanarayana PSV, et al. Quercetin, a bioflavonoid, protects against oxidative stress-related renal dysfunction by cyclosporine in rats. Methods Find Exp Clin Pharmacol 2001;23(4):175-81.
28. Shoskes DA & Manickam K. Herbal and complementary medicine in chronic prostatitis. World J Urol. 2003 Jun;21(2):109-13. Epub 2003 Apr 29. Review
29. Assessing Efficacy of Quercetin Supplement for Treatment of Women with Vulvodynia